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實驗室簡介：
本實驗室致力於疾病致病機轉之研究尋找相關致病基因途徑與危險因子，目前主要研究包括阿茲海默症致病機轉、口腔癌癌化基因途徑及醣化終極產物對疾病致病可能性之影響等相關研究。
研究計畫：
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計畫名稱
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補助或委託機構
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起訖年月
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計畫內擔任的工作
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醣化蛋白終極產物對口腔癌趨惡性影響之研究
(100-2314-B-309-002-MY3)
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行政院國家科學委員會
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2011/8/1至2014/7/31
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主持人
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類澱粉前趨蛋白質在口腔癌化中扮演角色之研究
(97-2314-B-309-001-MY3)
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行政院國家科學委員會
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2008/8/1至 2011/7/31
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主持人
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糖尿病併發阿茲海默症的可能性與作用機轉之研究
(96-2320-B-309-002-MY2)
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行政院國家科學委員會
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2007/3/1至 2008/7/31
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主持人
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大鼠心肌細胞中醣化蛋白終極產物對於環氧二型酵素影響之研究
(97-CCH-CJCU-01)
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彰化基督教醫院
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2008/3/1至 2009/2/28
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主持人
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紅血球生成素(erythropoietin), vitamin C 對 HepG2 細胞 Hepcidin 的調控研究(98-CCH-IRP-03)
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彰化基督教醫院
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2009/1/1至2009/12/31
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共同主持人
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異甘草素對口腔麟狀細胞癌之毒性研究
(CMU99-N1-11-1 & CMU99-N1-11-2)
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中國醫藥大學
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2010/10/1至2011/9/31
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共同主持人
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實驗技術：
期刊論文：
- Ko SY*, Lin YP, Lin YS, and Chang SS. Advanced glycation end products (AGEs) enhance amyloid precursor protein (APP) expression through inducing reactive oxygen species (ROS). Free Radical Biology & Medicine. 2010; 49(3): 474-480. (NSC 96-2320-B-309-002-MY2)
- Shieh TM, Chang KW, Tu HF, Shih YH, Ko SY, Chen YC, and Liu CJ. Association between the Hypoxia Inducible Factor-1α Polymorphisms and the Tumor Size of Oral Squamous Cell Carcinoma. Oral Oncology. 2010; 46:47-53. (NSC97-2314-B-039-041)
- Hsu YC, Chen MJ, Yu YM, Ko SY, and Chang CC. Suppression of TGF-b1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid. Arch Dermatol Res. 2010; 302(10):717-724
- Chen HI, and Ko SY. Editorial comment. Comment on: Urology. 2010 Aug;76(2):404-10. Urology.2010;76(2):410; discussion 410-1.
- Wu HT, Ko SY, Fong JH, Chang KW, Liu TY, Kao SY. Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation. J Oral Pathol Med. 2009; 38(2):206-13. (NSC-95-2314-B-075-075)
- Liu HC, Wang HC, Ko SY, Wang PN, Chi CW, Hong CJ, Lin KN, and Liu TY. Correlation between platelet amyloid precursor protein isoform ratio and cognition in Alzheimer’s disease. Journal of Alzheimer’s disease. 2007; 11: 77-84. (NSC 93-3112-B-010-23 and NSC 93-2314-B-010-008)
- Ko SY, Lin SC, Wong YK, Liu CJ, Chang KW, and Liu TY. Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma. Cancer Letters. 2007; 245: 33–43.
- Ko SY, Chang KW, Lin SC, Hsu HC, and Liu TY. The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo. Cancer Letters. 2007; 245: 81–89.
- Lin SC, Liu CJ, Ko SY, Chang HC, Liu TY, and Chang KW. Copy number amplification of 3q26-27 oncogenes in microdissected oral squamous cell carcinoma and oral brushed samples from areca chewers Journal of Pathology. J Pathol. 2005; 206(4): 417-422.
- Liu HC, Chi CW, Ko SY, Wang HC, Hong CJ, Lin KN, Wang PN, and Liu TY. Cholinesterase inhibitor affects the amyloid precursor protein isoforms in patients with Alzheimer’s disease. Dement Geriatr. Cogn. 2005; 19: 345-8. (NSC 92-3112-B-010-004 and NSC 92-2314-B-010-031)
- Ko SY, Lin SC, Chang KW, Wong YK, Liu CJ, Chi CW, and Liu TY. Increased expression of amyloid precursor protein in oral squamous cell carcinoma. Int J Cancer. 2004; 111(5): 727-32.
- Ko SY, Lin SC, Chang KW, Liu CJ, Chang SS, Lu SY, Liu TY. Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract. J Oral Pathol Med. 2003; 32(7): 399-407.
海報論文 ：
- Lin YS, Hsu YC, Chi CT, Chang SS, and Ko SY*. Advanced glycation end products (AGEs) induce reactive oxygen species (ROS) production and activate MEK-ERK pathway in H9c2 cells. The 25 th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2010.
- Chu PF, Chang CC, and Ko SY*. Ascorbate and erythropiebntin can modulate the expression of hepcidin within HepG2 cell. Organized by Taiwan Society of Nephrology, Taipei, Taiwan, 2008.
- Chu PF, Chang CC, and Ko SY*. Ascorbate can reverse the down-regulated erythropoientin receptors by erythropiebntin within HepG2 cell. Organized by Taiwan Society of Nephrology, Taipei, Taiwan, 2008.
- Lin YP and Ko SY*. Amyloid precursor protein (APP) expression is regulated by advanced glycation end products (AGEs) in SH-SY-5Y neuroblastoma cell line. The 23 th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2008.
- Ko SY, Lu CR and Liu TY. ERK1/2 phosphorylation is regulated by sAPPa and related oral cancer cell growth. The 4th Strait Bilateral Symposium on Toxicology, Taichung, Taiwan, 2007.
- Ko SY and Liu TY. Areca nut extract modulate amyloid precursor protein (APP) expression in vitro and invivo. The 15th World Congress of Pharmacology, Beijing, China. 2006.
- Liu TY, Chen CH, Ko SY, and Chi CW. Akr1c2 suppress cell proliferation and its relationship with prostaglandin E2 in oral cancer cells. International Eicosanoids Conference Basic Science & Clinical Applications Beijing, China. 2005.
- 陳慕聰，李麗珍，柯順耀，郭家驊。以基因晶片技術篩檢耐力型與速度型優秀運動員基因表現量之差異。北體學報。2004; 12: 83-93。
- 陳慕聰，李麗珍，林勁宏，柯信安，柯順耀。運動調控基因表現，國際運動與健康研討會，pp.103,2003/11，2003。
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